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Comparison of human nasal epithelial cells grown as explant outgrowth cultures or dissociated tissue

Jian Jiao, Na Meng, Hong Wang, Luo Zhang

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 486-491 doi: 10.1007/s11684-013-0287-x

Abstract: epithelial cells established as explant outgrowth cultures or dissociated tissue cultures.Human nasal mucosa of the uncinate process was obtained by endoscopy and epithelial cell cultures werecells.Overall, 10% of the cells in explant cultures and 20% of the cells in the dissociated tissue culturesof nasal epithelial cells in vivo.

Keywords： ciliated cells     ciliary beat frequency     dissociated tissue culture     explant culture     nasal epithelial cells    

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Hyperosmolarity promotes macrophage pyroptosis by driving the glycolytic reprogramming of corneal epithelialcells in dry eye disease

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 781-795 doi: 10.1007/s11684-023-0986-x

Abstract: In vitro, the indirect coculture of macrophages derived from THP-1 and human corneal epithelialcells (HCECs) was used to discuss the interaction among cells.

Keywords： dry eye disease     glycolytic reprogramming     pyroptosis     inflammation     2-DG    

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Abnormal expression of c-Myc in human bronchial epithelial cells malignantly transformed by anti-BPDE

FU Juan, JIANG Yiguo, CHEN Xuemin

Frontiers of Medicine 2008, Volume 2, Issue 4,   Pages 380-385 doi: 10.1007/s11684-008-0073-3

Abstract: Here, we investigated the expression of proto-oncogene c- in human bronchial epithelial cells (16HBE-TThe levels of mRNA and protein of c-Myc were examined in the 16HBE-T and vehicle-treated control cellsLikewise, the expression of c-Myc protein was significantly enhanced as compared with those of the control cellsconclusion, the abnormal expression of c-Myc was present in anti-BPDE malignantly transformed 16HBE cells

Keywords： transcriptase-polymerase     vehicle-treated     understood     molecular mechanism     different    

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Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota

Shari Garrett,Yongguo Zhang,Yinglin Xia,Jun Sun,

Engineering doi: 10.1016/j.eng.2023.06.007

Abstract: Intestinal homeostasis is maintained by specialized host cells and the gut microbiota.homeostasis and colitis, we generated new mouse models with Axin1 conditional knockout in intestinal epithelialThe absence of intestinal epithelial and PC Axin1 decreased susceptibility to dextran sulfate sodium-inducedHowever, the intestinal proliferative cells in Axin1ΔIEC mice with antibioticIn conclusion, we found that the loss of intestinal Axin1 protects against colitis, likely driven by epithelial

Keywords： Axin1     Bacteria     Microbiome inflammation     Inflammatory bowel disease     Immunity     Microbiome     Paneth cells     Akkermansia    

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Clinical outcomes and prognostic factors of patients with epithelial ovarian cancer subjected to first-line

Yunfeng Fu, Xinyu Wang, Zimin Pan, Xing Xie

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 91-95 doi: 10.1007/s11684-014-0305-7

Abstract:

A total of 251 patients with epithelial ovarian cancer (EOC) treated between 2002 and 2008 was retrospectively

Keywords： ovarian carcinoma     prognostic factors     surgery     chemotherapy     survival    

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Preventive effect of Shenkang injection against high glucose-induced senescence of renal tubular cells

Biqiong Fu, Jie Yang, Jia Chen, Lirong Lin, Kehong Chen, Weiwei Zhang, Jianguo Zhang, Yani He

Frontiers of Medicine 2019, Volume 13, Issue 2,   Pages 267-276 doi: 10.1007/s11684-017-0586-8

Abstract: Primary renal proximal tubule epithelial cells were cultured in (1) control medium (control group), mediumHG-induced senescent cells showed the emergence of senescence associated heterochromatin foci, up-regulationanti-senescence molecules klotho, sirt1, and peroxisome proliferator-activated receptor- in renal tubular epithelialcells.

Keywords： Shenkang injection     senescence     renal tubular epithelial cells     diabetic nephropathy    

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Epithelial-to-mesenchymal transition in cancer: complexity and opportunities

Yun Zhang, Robert A. Weinberg

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 361-373 doi: 10.1007/s11684-018-0656-6

Abstract:

The cell-biological program termed the epithelial-to-mesenchymal transition (EMT) plays an importantcontextual signals and intracellular gene circuits of a particular cell, this program can drive fully epithelialcells to enter into a series of phenotypic states arrayed along the epithelial-mesenchymal phenotypicCurrently we still lack a coherent overview of the molecular and biochemical mechanisms inducing cellsto enter various states along the epithelial-mesenchymal phenotypic spectrum.

Keywords： epithelial-to-mesenchymal transition     cancer     metastasis     cancer stem cell    

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Lymphatic metastasis is related to the epithelial-mesenchymal transition and expressions of VEGF, MMP

Lihui WANG, Lianhong LI, Shen LV, Shujun FAN, Li ZHAN, Bo WANG, Zhong ZHANG

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 164-170 doi: 10.1007/s11684-009-0038-1

Abstract: The invasion and metastasis of breast cancer are supposed to involve several stages in which epithelial-mesenchymaltransition (EMT) is regarded as the mechanistic basis for the behavior of cancer cells.

Keywords： epithelial-mesenchymal transition     vascular endothelial cell growth factor     matrix metalloproteinase-9    

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H. sinensis mycelium inhibits epithelial-mesenchymal transition by inactivating

Li Lu, Haiyan Zhu, Hailin Wang, Huaping Liang, Yayi Hou, Huan Dou

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 313-329 doi: 10.1007/s11684-020-0737-1

Abstract: The epithelial–mesenchymal transition (EMT) is involved in the pathogenesis of idiopathic pulmonary fibrosis

Keywords： epithelial−mesenchymal transition     H. sinensis mycelium     midkine     pulmonary fibrosis    

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Non-genetic mechanisms of diabetic nephropathy

Qiuxia Han, Hanyu Zhu, Xiangmei Chen, Zhangsuo Liu

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 319-332 doi: 10.1007/s11684-017-0569-9

Abstract: new molecular insights about the pathogenesis of DN from the aspects of immune inflammation response, epithelial

Keywords： diabetic nephropathy     immune inflammatory response     epithelial–mesenchymal transition     apoptosis     mitochondrial    

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Porcine pluripotent stem cells: progress, challenges and prospects

Jianyong HAN, Yi-Liang MIAO, Jinlian HUA, Yan LI, Xue ZHANG, Jilong ZHOU, Na LI, Ying ZHANG, Jinying ZHANG, Zhonghua LIU

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 8-27 doi: 10.15302/J-FASE-2018233

Abstract:

Pluripotent stem cells (PSCs) are characterized by their capacity for high self-renewal and multipledifferentiation potential and include embryonic stem cells, embryonic germ cells and induced PSCs.

Keywords： embryonic germ cells     embryonic stem cells     induced pluripotent stem cells     pigs     pluripotent stem cells    

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Determination of telomerase activity in stem cells and non-stem cells of breast cancer

LI Zhi, HE Yanli, ZHANG Jiahua, ZHANG Jinghui, HUANG Tao

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 294-298 doi: 10.1007/s11684-007-0056-9

Abstract: Although all normal tissue cells, including stem cells, are genetically homologous, variation in geneIn normal adults, telomerase activation mainly presents in tissue stem cells and progenitor cells givingand only minorities of cells, designated as cancer stem cells, undergo processes analogous to the self-renewalcells that were phenotypically sorted by examining surface marker expression.The results indicated that cancer stem cells show a higher level of enzyme activity than non-stem cells
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Innate and adaptive T cells in influenza disease

Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H.O. Nguyen, Katherine Kedzierska

Frontiers of Medicine 2018, Volume 12, Issue 1,   Pages 34-47 doi: 10.1007/s11684-017-0606-8

Abstract: and antibody-producing B cells) achieve viral clearance and host recovery.Adaptive T and B cells maintain immunological memory and provide protection against subsequent infectionsRecent studies also shed light on the role of innate T-cells (MAIT cells, gd T cells, and NKT cells)We summarize the current knowledge on influenza-specific innate MAIT and gd T cells as well as adaptiveCD8+ and CD4+ T cells, and discuss how these responses can be harnessed by novel

Keywords： influenza     innate T cells     CD4+ and CD8+ T cells     vaccination    

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Reprogramming of the pig primordial germ cells into pluripotent stem cells: a brief review

Qijing LEI, Qin PAN, Shuai YU, Na LI, Shulin CHEN, Kuldip SIDHU, Jinlian HUA

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 28-32 doi: 10.15302/J-FASE-2018222

Abstract:

Primordial germ cells (PGCs) are regarded as unipotent cells that can produce only either spermatogoniaHowever, PGCs can be converted into the pluripotent state by first dedifferentiation to embryonic germ cellsand then by reprogramming to induce them to become pluripotent stem cells (iPSCs).These two stages can be completely implemented with mouse cells.

Keywords： pig     pluripotent stem cells     primordial germ cells     reprogramming    

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4-1BBL expressed by eukaryotic cells activates immune cells and suppresses the progression of murine

Hui QIU, Hui ZHANG, Zuohua FENG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 20-25 doi: 10.1007/s11684-009-0006-9

Abstract: The function of 4-1BB/4-1BBL expressed by the immune cells has been the focus for many tumor immunotherapyIn this study, 4-1BBL was expressed in non-immune cells and non-tumor cells, and the role of 4-1BBL in-1BBL cDNA sequence was constructed, and the plasmid was transfected into baby hamster kidney (BHK) cellsand murine muscle cells by means of lipofectin-mediated or naked plasmid DNA injection into the muscleThe study demonstrated that the molecule 4-1BBL expressed by BHK cells could enhance the proliferation

Keywords： 4-1BB ligand     tumor immunotherapy     tumor microenvironment    

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Title Author Date Type Operation

Comparison of human nasal epithelial cells grown as explant outgrowth cultures or dissociated tissue

Jian Jiao, Na Meng, Hong Wang, Luo Zhang

Journal Article

Hyperosmolarity promotes macrophage pyroptosis by driving the glycolytic reprogramming of corneal epithelialcells in dry eye disease

Journal Article

Abnormal expression of c-Myc in human bronchial epithelial cells malignantly transformed by anti-BPDE

FU Juan, JIANG Yiguo, CHEN Xuemin

Journal Article

Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota

Shari Garrett,Yongguo Zhang,Yinglin Xia,Jun Sun,

Journal Article

Clinical outcomes and prognostic factors of patients with epithelial ovarian cancer subjected to first-line

Yunfeng Fu, Xinyu Wang, Zimin Pan, Xing Xie

Journal Article

Preventive effect of Shenkang injection against high glucose-induced senescence of renal tubular cells

Biqiong Fu, Jie Yang, Jia Chen, Lirong Lin, Kehong Chen, Weiwei Zhang, Jianguo Zhang, Yani He

Journal Article

Epithelial-to-mesenchymal transition in cancer: complexity and opportunities

Yun Zhang, Robert A. Weinberg

Journal Article

Lymphatic metastasis is related to the epithelial-mesenchymal transition and expressions of VEGF, MMP

Lihui WANG, Lianhong LI, Shen LV, Shujun FAN, Li ZHAN, Bo WANG, Zhong ZHANG

Journal Article

H. sinensis mycelium inhibits epithelial-mesenchymal transition by inactivating

Li Lu, Haiyan Zhu, Hailin Wang, Huaping Liang, Yayi Hou, Huan Dou

Journal Article

Non-genetic mechanisms of diabetic nephropathy

Qiuxia Han, Hanyu Zhu, Xiangmei Chen, Zhangsuo Liu

Journal Article

Porcine pluripotent stem cells: progress, challenges and prospects

Jianyong HAN, Yi-Liang MIAO, Jinlian HUA, Yan LI, Xue ZHANG, Jilong ZHOU, Na LI, Ying ZHANG, Jinying ZHANG, Zhonghua LIU

Journal Article

Determination of telomerase activity in stem cells and non-stem cells of breast cancer

LI Zhi, HE Yanli, ZHANG Jiahua, ZHANG Jinghui, HUANG Tao

Journal Article

Innate and adaptive T cells in influenza disease

Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H.O. Nguyen, Katherine Kedzierska

Journal Article

Reprogramming of the pig primordial germ cells into pluripotent stem cells: a brief review

Qijing LEI, Qin PAN, Shuai YU, Na LI, Shulin CHEN, Kuldip SIDHU, Jinlian HUA

Journal Article

4-1BBL expressed by eukaryotic cells activates immune cells and suppresses the progression of murine

Hui QIU, Hui ZHANG, Zuohua FENG

Journal Article